The 3D-Bioplotter® System is the premier bioplotter on the market today with over 400 peer reviewed research papers written on research performed with this plotter. It is a versatile rapid prototyping tool for processing a large variety of biomaterials for computer-aided tissue engineering (CATE), from 3D CAD models and patient CT data to the physical 3D scaffold with a designed and defined outer form and an open inner structure. The range of materials, the largest of any singular rapid prototyping machine, includes soft hydrogels, polymer melts ,live cells, hard ceramics and even metals. Complex inner patterns can easily be designed using the 3D-Bioplotter® software to control the mechanical properties, increase cell adhesion, as well as improve the flow of nutrient media throughout the interconnecting pores of the printed implants.